Washington became a symbol of the American Revolution after her husband was appointed commander-in-chief of the Continental Army, and she took on a matronly role while visiting encampments when fighting stalled each winter. Her only surviving child, John, died from a camp illness during the war. After the war ended in 1783, Washington sought retirement at Mount Vernon, but she was returned to public life when her husband became president of the United States in 1789.

Washington took on the social role of the president's wife reluctantly, becoming a national celebrity in the process. She found this life unpleasant, feeling that she was restricted and wishing for retirement. In addition to hosting weekly social events, Washington understood that how she composed herself would reflect on the nation, both domestically and abroad. As such, she struck a careful balance between the dignity associated with a head of state's wife and the humility associated with republican government.

The Washingtons returned to Mount Vernon in 1797, and she spent her retirement years greeting admirers and advising her successors. She was widowed for a second time in 1799, and she died two and a half years later in 1802.