Angelica Schuyler Church's adult activity centered on family management, correspondence and the social connections linking American and European political circles. After marrying the merchant John Barker Church in 1777, she moved with her family to Europe in 1783. In Paris she formed friendships with figures including Benjamin Franklin, Thomas Jefferson and Lafayette. In London her acquaintances included Charles James Fox, Richard Brinsley Sheridan and the artists John Trumbull and Maria Cosway.

Church maintained contact across the Atlantic through letters to relatives and friends, her sister Elizabeth Hamilton and brother-in-law Alexander Hamilton. The correspondence carried political discussion, introductions and family news with books and gifts. During the debate over the proposed United States Constitution, she sent Jefferson a copy of The Federalist. Her support for Trumbull and her role in obtaining a London piano for her niece Angelica illustrate the cultural exchanges sustained through these networks.

She oversaw her children’s education and travelled between Britain, France and America. She visited New York for Washington's inauguration in 1789 and returned permanently in 1799. The family later planned Belvidere, a house in western New York, though it became her son's residence. The village of Angelica was named for her. She continued her family relationships and correspondence until her death in 1814, leaving observations of the revolutionary Atlantic world.