George Wythe Randolph died of tuberculosis at Edgehill near Charlottesville, Virginia, on April 3, 1867, aged forty-nine. His final years were marked by a search for relief from the disease. After serving briefly as Confederate secretary of war in 1862, he left public office amid disagreements with Jefferson Davis and worsening health. In 1864 he and his wife traveled through the naval blockade to Europe, where he sought medical help in England and southern France. The change of surroundings did not restore him. He took the United States oath of allegiance in France in 1866 and returned to Virginia later that year. Death followed at the family home the next spring. The course supports a prolonged pulmonary illness and unsuccessful efforts to improve his health, but the consulted account does not provide a complete list of therapies or the symptoms of his final hours. He was buried in the Jefferson family graveyard at Monticello. His grandfather Thomas Jefferson's death in 1826 is a separate event; Randolph's own end belongs to the years immediately after the Civil War and to the tuberculosis that had constrained his later life.