Educated at William and Mary and in Philadelphia, he joined the family business and inherited wealth. During the Revolution he served on Virginia’s Navy Board and Board of Trade, then its Council of State. Appointed treasurer in 1782, he held the post until his death and helped supervise the new Richmond Capitol. Ambler served on public boards and the state council and held the treasurership. Jaquelin Ambler died in 1798, in Richmond, Henrico, Virginia, United States. The available biographical account does not describe a continuous final medical course. It gives no dependable sequence of treatment and last symptoms from which to reconstruct a more detailed bedside narrative.