Esther Edwards Burr died on April 7, 1758, aged twenty-six, during the succession of illnesses and losses that struck the Edwards and Burr families. Her husband Aaron Burr Sr. had died the previous year, leaving her with two young children. Her father Jonathan Edwards then died in March 1758 after smallpox inoculation. Esther's own fatal illness followed soon afterward and is commonly identified as smallpox, although descriptions in the biographical tradition are not entirely consistent. That uncertainty limits any attempt to reconstruct a precise clinical course or attribute every symptom to a confirmed infection. The material consulted does not provide a dependable treatment history or a complete account of the final day. The important distinction is between her illness and the separate death of her father, whose inoculation has often dominated the family narrative. Her death left Sarah and the future vice president Aaron Burr orphaned, and her mother Sarah Edwards died later the same year. Those consequences explain why the period was remembered as a devastating family sequence. Esther's journal and friendships preserve far more of her earlier inner life than the surviving accounts preserve of her final bedside circumstances. Her ending should therefore retain the reported disease and close chronology without inventing exact symptoms or last words.